Development and Functions of Antigen-Presenting Cells

Antigen-Presenting Cells are important immune regulators and play a central role in regulating T cell-mediated immunity.

To defeat distinct types of pathogens while maintaining immune homeostasis, a diverse group of Antigen-Presenting Cells has evolved, each with specialized functions in T cell priming.

We study the gene regulatory networks governing Antigen-Presenting Cell development, and develop genetically engineered mouse models to reveal the overlapping and unique functions of each Antigen-Presenting Cell subset.

Our long-term goal is to leverage these insights to develop innovative vaccines and therapies that modulate T cell responses for the treatment of infectious diseases, autoimmune disorders, and cancer.