Publications
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development
Chen J, Liu TT, Ou F, Ohara RA, Jo S, Postoak JL, Egawa T, Day RB, Murphy TL, Murphy KM, Kim S.
Science Immunology. 10, eadt5899 (2025). Full Text
Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation
Ou F, Liu TT, Desai P, Ferris ST, Kim S, Shen H, Ohara RA, Jo S, Chen J, Postoak JL, Du S, Diamond MS, Murphy TL, Murphy KM.
Nature Immunology. 25, 2043-2056 (2024). Full Text
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy
Sultan H, Takeuchi Y, Ward JP, Sharma N, Liu TT, Sukhov V, Firulyova M, Song Y, Ameh S, Brioschi S, Khantakova D, Arthur CD, White JM, Kohlmiller H, Salazar AM, Burns R, Costa HA, Moynihan KD, Yeung YA, Djuretic I, Schumacher TN, Sheehan KCF, Colonna M, Allison JP, Murphy KM, Artyomov MN, Schreiber RD.
Nature. 632, 182-191 (2024) Full Text
Transcription factor C/EBPα is required for the development of Ly6C(hi) monocytes but not Ly6C(lo) monocytes
Kim S, Chen J, Ou F, Liu TT, Jo S, Gillanders WE, Murphy TL, Murphy KM.
Proc Natl Acad Sci U S A. 121, e2315659121 (2024) Full Text
IL-6 selectively suppresses cDC1 specification via C/EBPβ
Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM.
Journal of Experimental Medicine. 220, e20221757 (2023) Full Text
Bcl6, Irf2, and Notch2 promote nonclassical monocyte development
O'Connor KW, Liu TT, Kim S, Briseño CG, Georgopoulos K, Murphy TL, Murphy KM.
Proc Natl Acad Sci U S A. 120, e2220853120 (2023) Full Text
Cis interactions in the Irf8 locus regulate stage-dependent enhancer activation
Liu TT, Ou F, Belk JA, Bagadia P, Anderson DA 3rd, Durai V, Yao W, Satpathy AT, Murphy TL, Murphy KM.
Genes & Development. 37, 291-302 (2023) Full Text
WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis
Ferris ST, Liu TT, Chen J, Ohara RA, Ou F, Wu R, Kim S, Murphy TL, Murphy KM.
Proc Natl Acad Sci U S A. 120, e2219956120 (2023) Full Text
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
Wu R, Ohara RA, Jo S, Liu TT, Ferris ST, Ou F, Kim S, Theisen DJ, Anderson DA 3rd, Wong BW, Gershon T, Schreiber RD, Murphy TL, Murphy KM.
Nature Immunology. 23, 1536-1550 (2022) Full Text
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer
Liu TT, Kim S, Desai P, Kim DH, Huang X, Ferris ST, Wu R, Ou F, Egawa T, Van Dyken SJ, Diamond MS, Johnson PF, Kubo M, Murphy TL, Murphy KM.
Nature. 607, 142-148 (2022) Full Text
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity
Kim S, Bagadia P, Anderson DA 3rd, Liu TT, Huang X, Theisen DJ, O'Connor KW, Ohara RA, Iwata A, Murphy TL, Murphy KM.
Immunity. 53, 759-774.e9 (2020) Full Text
Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development
Bagadia P*, Huang X*, Liu TT*, Murphy KM. (* indicates equal contributions).
Annual Review of Cell and Developmental Biology. 35, 381-406 (2019) Full Text
An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development
Bagadia P*, Huang X*, Liu TT*, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. (* indicates equal contributions).
Nature Immunology. 20, 1174-1185 (2019) Full Text
TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses
Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM, Shu HB.
PLOS Pathogens. 13, e1006600 (2017) Full Text
LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner
Liu TT, Yang Q, Li M, Zhong B, Ran Y, Liu LL, Yang Y, Wang YY, Shu HB.
The Journal of Immunology. 196, 5101-5111 (2016) Full Text
SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB.
Journal of Molecular Cell Biology. 3, 283-292 (2011) Full Text